The Afterbirth expansion for The Binding of Isaac: Rebirth was released, adding new items, enemies, bosses, and gameplay modes.
An expansion pack for Afterbirth named Afterbirth+ was released, including mod support and additional content.
The Repentance expansion, the largest content update for The Binding of Isaac: Rebirth, was released, adding substantial new content, quality of life improvements, and a new final chapter.
Isaac lives with his deeply religious mother and has a generally sheltered and troubled childhood marked by fear and religious fanaticism.
Isaac's mother believes she receives a direct command from God to sacrifice Isaac as a test of faith.
Fleeing his mother's attempt to sacrifice him, Isaac descends into the basement of their home, beginning his journey through the dark and dangerous underworld beneath his house.
Isaac confronts numerous grotesque and supernatural creatures in the basement levels, testing his survival and combat skills.
Isaac discovers strange items and power-ups that enhance his abilities and alter his form, each reflecting aspects of his psyche and trauma.
At various points, Isaac faces inner visions and manifestations of his mother, symbolizing his struggle against his past and religious fanaticism.
Isaac finally confronts the manifestation of his mother's heart in the depths of the basement, symbolizing ultimate confrontation with his trauma.
Depending on player actions, Isaac faces various endings that suggest different fates—some hopeful, some tragic, including escape, demise, or further descent into madness.
