Isaac Clarke wakes up from a coma in a hospital on the Sprawl station after the events on the Ishimura.
Necromorph infection breaks out on the Sprawl, a massive space station orbiting Saturn's moon Titan.
Isaac and survivors try to escape the station, but most evacuation attempts are thwarted by Necromorph infestations and system failures.
Isaac encounters members of the Unitology cult, who believe the Necromorph outbreak is a path to salvation and actively interfere with his mission.
Isaac learns that his own memories and hallucinations are influenced by marker-induced visions; he struggles with his sanity.
Isaac infiltrates the Sprawl's Marker chamber and successfully destroys the Marker, halting the Necromorph infection's source.
After destroying the Marker, Isaac attempts to flee the Sprawl amidst ongoing chaos and destruction.
The Sprawl's AI initiates a self-destruct sequence to contain the Necromorph outbreak, forcing Isaac into a final desperate push to escape.
