The original 'Fullmetal Alchemist' anime adaptation airs in Japan, based on the early volumes of the manga.
'Fullmetal Alchemist: Brotherhood,' a more faithful anime adaptation to the manga, begins airing in Japan.
The 'Fullmetal Alchemist' manga series concludes after 108 chapters.
The 'Fullmetal Alchemist: Brotherhood' anime finishes airing its 64-episode run.
Edward and Alphonse Elric are born to Hohenheim and Trisha Elric.
Edward and Alphonse attempt human transmutation to bring back their mother, resulting in Edward losing his leg and Alphonse his entire body. Edward sacrifices his arm to bind Alphonse's soul to armor.
Edward receives automail prosthetics and passes the State Alchemist exam, becoming the Fullmetal Alchemist.
Edward and Alphonse join forces with Roy Mustang's unit and begin investigating the Philosopher's Stone and Homunculi.
The brothers discover the true nature of the Philosopher's Stone and Father's origins.
Final confrontation between Edward, Alphonse, their allies, and Father’s forces including Homunculi.
Father is defeated, and Alphonse's physical body is restored.
Edward travels to learn more about alchemy beyond Amestris; the future of the brothers is hopeful and open.