The manga series Gunslinger Girl, written and illustrated by Yu Aida, was first published in Japan.
The first season of the Gunslinger Girl anime adaptation aired in Japan, bringing the manga series to a wider audience.
The second season of the Gunslinger Girl anime, titled Gunslinger Girl: Il Teatrino, premiered in Japan as a continuation of the story.
Establishment of the Social Welfare Agency, initiating the cybernetic augmentation program for young girls.
Young girls, mostly orphans, are recruited and given cybernetic enhancements to become agents.
Henrietta, a cybernetic agent, undertakes a mission involving capturing terrorist leader Calderone.
Jose becomes the primary handler for Henrietta, forging a complex relationship.
Angelica carries out covert operations involving political assassination.
Rico, another agent, suffers a grave injury leading to complications in agency operations.
Internal conflicts arise as some members question the ethical implications of using young girls as cybernetic assassins.
A series of final missions leading to the near collapse or exposure of the Agency.
