The Nintendo Wii gaming console is released, providing innovative motion controls that influence the design and gameplay of future titles such as Trauma Center: Second Opinion.
Trauma Center: Second Opinion is released for the Nintendo Wii, featuring motion-controlled surgery gameplay and expanded content from the original DS version.
Derek Stiles graduates from medical school and begins his residency at Hope Hospital.
The rare and dangerous GUILT pathogen is first identified in Japan, posing a new medical threat.
Dr. Derek Stiles officially joins the surgical team at Hope Hospital, where he will face the GUILT crisis.
Multiple patients infected with different strains of GUILT begin appearing in Hope Hospital.
Stiles successfully performs complex surgeries to remove GUILT infections from patients' bodies despite the pathogen's resilience.
Naomi Kimishima joins as a surgical assistant and becomes a key partner in combating GUILT.
A new and highly dangerous strain of GUILT, named Renas, emerges and complicates treatment procedures.
Dr. Stiles faces the most severe case yet, performing a challenging surgery to remove the Renas GUILT and save the patient’s life.
With successful treatments, the GUILT outbreak comes under control, and normal hospital functions resume.
