The first episode of The Big Bang Theory aired on CBS, introducing the world to the lives of physicists Leonard and Sheldon and their friends.
Jim Parsons, who plays Sheldon Cooper, won his first Primetime Emmy Award for Outstanding Lead Actor in a Comedy Series for his role on The Big Bang Theory.
Mayim Bialik debuted as Amy Farrah Fowler, Sheldon's love interest, significantly impacting the show's dynamics.
Season 5 of The Big Bang Theory became the highest-rated season, solidifying the show's popularity.
The show hit a major milestone by airing its 200th episode, showcasing its longevity and success.
CBS announced that the show would end after its 12th season, marking the beginning of the series conclusion phase.
The series finale of The Big Bang Theory aired on CBS, ending the beloved sitcom after 12 seasons.
Leonard and Sheldon become roommates in an apartment in Pasadena, California, setting the stage for their friendship and the show's main setting.
Penny moves into the apartment across the hall from Sheldon and Leonard, introducing a new dynamic to the group.
Howard Wolowitz and Raj Koothrappali, friends and fellow scientists, join the central friend group.
Leonard and Penny begin their on-again, off-again romantic relationship, a central plotline of the series.
Sheldon meets Amy Farrah Fowler through an online dating service arranged by the group, marking the beginning of their relationship.
Bernadette Rostenkowski, initially Penny's coworker, becomes part of the group and later marries Howard.
Howard Wolowitz and Bernadette Rostenkowski marry, solidifying friendships within the group.
Sheldon Cooper and Amy Farrah Fowler marry, culminating their long-term relationship.
Leonard and Penny get married, confirming their relationship's stability.
Raj learns to talk to women without needing to be intoxicated, showing significant personal growth.
Sheldon and Amy jointly receive the Nobel Prize in Physics for their work on super asymmetry.
