Arthur Conan Doyle creates the character Sherlock Holmes, first appearing in 'A Study in Scarlet'.
The second Sherlock Holmes novel, 'The Sign of the Four', is published, further defining the character.
Sherlock Holmes stories begin serialization in The Strand Magazine, popularizing the character widely.
Dr. John Watson is introduced as Sherlock Holmes’s companion and chronicler in the first novel.
Sherlock Holmes is presumed dead after confronting Professor Moriarty at Reichenbach Falls in 'The Final Problem'.
Due to public demand, Conan Doyle brings Sherlock Holmes back in 'The Adventure of the Empty House'.
The earliest known film adaptation of Sherlock Holmes is produced, marking the character's screen debut.
Basil Rathbone begins his iconic portrayal of Sherlock Holmes in films, defining the character for generations.
The modern television adaptation 'Sherlock' starring Benedict Cumberbatch premieres, revitalizing interest in the character.
Sherlock Holmes is born in 1854, laying the foundation for the future legendary detective.
Holmes meets Dr. John H. Watson at St. Bartholomew's Hospital, beginning their famous partnership and friendship.
Holmes and Watson take on their first major case together involving a mysterious treasure and secret pact.
Holmes and Watson move to 221B Baker Street, which becomes the iconic base of operations for their detective work.
Holmes investigates the legend of a supernatural hound terrorizing the Baskerville family on the Devonshire moors.
Holmes reveals to Watson that he survived his apparent death at Reichenbach Falls and returns to London to continue his investigative career.
Holmes confronts his nemesis, Professor Moriarty, at Reichenbach Falls; presumed dead after the struggle.
