Niccolò Machiavelli, Florentine diplomat and philosopher referenced in Renaissance Italy, was born.
The city of Constantinople fell to the Ottoman Turks, an event that deeply impacted Renaissance politics and is indirectly referenced in the game's setting.
The flourishing of culture, arts, and humanism in Italy began, setting the backdrop for much of Assassin's Creed II’s events.
Lorenzo de’ Medici, a major patron of the arts and ruler of Florence, whose period of influence corresponds with the game's timeline.
Christopher Columbus embarked on his first voyage to the New World, marking the beginning of European colonization in the Americas.
The Pazzi conspiracy, an attempt to overthrow the Medici family in Florence, including the assassination of Giuliano de’ Medici, took place.
Ezio Auditore finds the Apple of Eden, a powerful Piece of Eden, in the Vatican archives.
Ezio assassinate Uberto Alberti, a member of the Templar conspiracy responsible for his father's death.
Ezio witnesses the execution of his father and brothers, sparking his quest for revenge against the Templars.
Ezio meets Leonardo da Vinci, who becomes his ally and helps upgrade his equipment and technology.
Ezio collects multiple Codex pages scattered across Italy, unlocking knowledge about the Pieces of Eden.
Ezio assassinates Rodrigo Borgia, the Grand Master of the Templar Order, during the Papal conclave.
Ezio forms alliances with Bartolomeo d'Alviano and Niccolò Machiavelli, strengthening the Assassin Order.
Ezio fights alongside Bartolomeo d'Alviano and the loyalists during the Battle of Forlì against the Borgia forces.
Ezio frees Venice from the control of the Borgia family, weakening their influence in the region.
Ezio confronts Cesare Borgia and defeats him, effectively ending the Borgia's dominance in Italy.
