The video game The Powerpuff Girls: Defenders of Townsville was released for PlayStation 2 and Xbox platforms, allowing fans of the animated series to play as the Powerpuff Girls and combat villains in Townsville.
Professor Utonium accidentally adds a mysterious new chemical compound to the usual mixture, enhancing the Powerpuff Girls' powers just before the main events of the game.
Villains Mojo Jojo, HIM, and others launch coordinated attacks on Townsville leaving the city in chaos.
The Powerpuff Girls respond to the multiple crises across Townsville, engaging in battles to defend citizens and infrastructure.
Mojo Jojo attempts to rob the Townsville Bank; the Girls confront him to prevent disaster and capture him again.
HIM unleashes a dark force causing shadows to terrorize the population, pushing the Girls to investigate the source.
Chemical explosions threaten the power plant; the Girls must rescue trapped workers and stabilize the plant.
The Powerpuff Girls enter Mojo Jojo's lair to stop his plans for world domination, leading to an intense final battle.
After defeating the villains, the Powerpuff Girls help restore order and ensure the safety of Townsville citizens.
